Synthesis of new series of pyrimidine nucleoside derivatives bearing the acyl moieties as potential antimicrobial agents

Nucleoside derivatives are important therapeutic drugs and the focal point in ongoing search for novel, more potent drug targets. In this study, a new series of pyrimidine nucleoside i.e., uridine ( 1 ) were synthesized via direct method evaluated their antimicrobial potential activity. The title compound was treated with triphenylmethyl chloride pyridine to give 5´- O -(triphenylmethyl)uridine derivative 2 ), which subsequently derivatized create 2´,3´-di- -acyl analogs containing wide variety functionalities single molecular framework. vitro functionality tests determined against both human plant pathogens by disc diffusion food poisoned techniques. chemical structures compounds confirmed on basis spectral, analytical, physicochemical data. results indicated that exhibited moderate good antibacterial antifungal activity; particular, they found be effective fungal phytopathogens than bacterial strains. Compounds 7 , 9 14 particular interest as noteworthy properties. MTT assays revealed Ehrlich’s ascites carcinoma (EAC) cells, resulting 7.12% 1.34% cell growth inhibition at concentrations 200 6.25 µg/ml, respectively. IC 50 value rather high 1956.25 µg/ml. Structure-activity relationship (SAR) studies also conducted predict structural pharmacokinetic findings study indicate different potentially useful agents advancement future pharmaceutical research.